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overuse of antibiotics is a growing problem

How Excessive Antibiotic Use Can Lead To Antibiotics Resistance

By Jun Kim Ph.D.

With the recent news about a woman who died from a superbug infection, antibiotic resistance has been gaining increased attention. Global leaders recently met at a UN meeting to discuss future actions on antimicrobial resistance, along with prominent figures such as Bill Gates warning us of potential threats to our health. 

The fact that antibiotic resistance is occurring is hardly surprising. After all, that is how evolution happens through natural selection. But the problem is excessive use of antibiotics seems to have accelerated the process. Let's discuss the potential downfalls of using too many unnecessary antibiotics. 

The Antibiotics Problem

After penicillin was successfully used in the 1940s, penicillin resistance soon became a significant problem by the 1950s 1. In response, new beta-lactam antibiotics were used, but the first case of methicillin-resistant Staphylococcus aureus (MRSA) was identified during that same decade 1.

According to the Centers for Disease Control and Prevention (CDC), now there are over 80,000 MRSA infections and 11,285 related deaths every year in the US.

Mechanisms behind antibiotic resistance have been studied extensively. Some bacteria can be intrinsically resistant to certain antibiotics because of structural or functional characteristics. For example, a species can be missing a molecular that the drug targets or have a cell surface membrane the drug cannot penetrate. 

Other types of bacteria that were initially responsive can also acquire resistance via mutations in genes or by receiving these genes from other bacteria 2. Such mutations can reduce the concentration of the drug in the cell, modify the drug target gene by mutation, or modify the antibacterial drug.

The Problems of Unnecessary Antibiotic Use

The unnecessary use of antibiotics can promote the development of antibiotic resistance by supporting genetic alterations, such as changes in gene expression, gene transfer between species, and mutagenesis 3.

Also, antibiotics often remove drug-sensitive competitors because these drugs tend not to be very specific, and this leaves resistant bacteria behind to grow 4. 

The healthy gut flora provides an important host defense. They inhibit the overgrowth of c. difficile and other potential pathogens through competition for nutrients and intestinal niches and induction of host immune responses. 

Antibiotic therapy can weaken this host defense by disrupting the indigenous gut flora, which makes the host more vulnerable to C. difficile during the treatment and during the period of microflora recovery 5.

Why Antibiotics Might Be Less Effective Now

Another important contributing factor to the rapid increase in untreatable infections is a lack of new drugs. Because of economic and regulatory obstacles, pharmaceutical companies are moving away from antibiotic development. 

For example, because antibiotics are used for relatively short periods and are often curative, antibiotics are not as profitable as drugs that treat chronic conditions.

In terms of price, antibiotics are generally at a maximum of $1000 to $3000 per course compared with cancer chemotherapy that costs tens of thousands of dollars 6.

Also, now that antibiotic resistance is becoming a widely noticed issue, restrained use of antibiotics will hold the new drugs in reserve for only the worst cases to prevent the development of further drug resistance 6. Understandably, of the 18 largest pharmaceutical companies, 15 abandoned the antibiotic field 7.

Probiotics and Antibiotics

It was discussed in the previous articles (here & here) that probiotics may prevent infections by providing antimicrobial agents, boosting host's immune system, decreasing intestinal permeability, and competing with pathogens for space and nutrients in the host.  

Studies have shown that concomitant use of probiotics with antibiotics reduces the risk for antibiotic-associated symptoms. Although the extent to which probiotics directly reduce the spread of antibiotic resistance is unclear, maintaining a balanced microbiota during antibiotic use does provide opportunities for reducing the spread of resistance 8. 

Most of the research conducted on antibiotic resistance has been focused on pathogenic bacteria prevalent in nosocomial settings such as hospitals and nursing home environments. 

However, it is also important to study antibiotic resistance in animal food production as well as aquaculture. Therefore, using probiotics in the feed and thus improving animal health could be an important approach to reduce the spread of antibiotic resistance.

You can also improve your own gut microbiome and perhaps, decrease your need for antibiotics. Diversify your gut microbiome to fight off pathogenic attacks. Get your gut tested with Ombre. 

Receive personalized food recommendations that will help you meet your wellness goals. Also, consider opting into a strain-specific probiotic subscription. These formulas are clinically backed to address your daily symptoms. Reclaim your gut health with Ombre today. 

Resources

  • 1 Sengupta S, Chattopadhyay MK, Grossart HP: The multifaceted roles of antibiotics and antibiotic resistance in nature. Front Microbiol 2013, 4:47.
  • 2 Blair JMA, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJV: Molecular mechanisms of antibiotic resistance. Nat Rev Micro 2015, 13:42–51.
  • 3 Viswanathan VK: Off-label abuse of antibiotics by bacteria. Gut Microbes 2014, 5:3–4.
  • 4 Read AF, Woods RJ: Antibiotic resistance management. Evol Med Public Health 2014, 2014:147.
  • 5 Owens RC, Jr., Donskey CJ, Gaynes RP, Loo VG, Muto CA: Antimicrobial-associated risk factors for Clostridium difficile infection. Clin Infect Dis 2008, 46 Suppl 1:S19–31.
  • 6 Gould IM, Bal AM: New antibiotic agents in the pipeline and how they can help overcome microbial resistance. Virulence 2013, 4:185–191.
  • 7 Bartlett JG, Gilbert DN, Spellberg B: Seven ways to preserve the miracle of antibiotics. Clin Infect Dis 2013, 56:1445–1450.
  • 8 Ouwehand AC, Forssten S, Hibberd AA, Lyra A, Stahl B: Probiotic approach to prevent antibiotic resistance. Ann Med 2016, 48:246–255.